{"id":12,"date":"2014-06-18T22:39:38","date_gmt":"2014-06-18T22:39:38","guid":{"rendered":"http:\/\/www.brign.com\/br-minimal\/?page_id=12"},"modified":"2024-08-29T19:30:34","modified_gmt":"2024-08-29T19:30:34","slug":"research","status":"publish","type":"page","link":"https:\/\/pbbp.unist.ac.kr\/?page_id=12","title":{"rendered":"Research"},"content":{"rendered":"An ultimate complexity is the machinery of life. From molecules to populations, from biochemistry to ecology, the devil is in the detail. The \"reductionist\" approaches that have led to resounding success\u00a0in physical science seem reckless considering the formidable biological details. What can we do? Here is the need for phenomenology based on biological numeracy and\u00a0quantitative\u00a0abstraction. A\u00a0success story comes from the earlier development of thermodynamics, where the notions of atoms and molecules had remained only a metaphysical insight. We try to find, in close collaboration with wet biologists, effective coarse-graining schemes that map \"form\" onto \"function\" and vice versa.\r\n\r\n\r\nNature, Nurture, and \"Chance\"\r\nStochastic fluctuations in a cell: noise propagation in signal transduction, transcription regulation, and cellular metabolism.\r\n\r\nChemical kinetics of a single enzyme and dynamic disorder\r\n\r\n\r\nMicrobial Cell Factory\r\nConstraint-based modeling for synthetic biology and metabolic <a href=\"https:\/\/pbbp.unist.ac.kr\/?page_id=12\" class=\"more-link\">Read more<\/a>","protected":false},"excerpt":{"rendered":"<p>An ultimate complexity is the machinery of life. From molecules to populations, from biochemistry to ecology, the devil is in the detail. The &#8220;reductionist&#8221; approaches that have led to resounding success\u00a0in physical science seem reckless considering the formidable biological details. What can we do? Here is the need for phenomenology based on biological numeracy and\u00a0quantitative\u00a0abstraction. A\u00a0success story comes from the earlier development of thermodynamics, where the notions of atoms and molecules had remained only a metaphysical insight. We try to find, in close collaboration with wet biologists, effective coarse-graining schemes that map &#8220;form&#8221; onto &#8220;function&#8221; and vice versa. Nature, Nurture, and &#8220;Chance&#8221; Stochastic fluctuations in a cell: noise propagation in signal transduction, transcription regulation, and cellular metabolism. Chemical kinetics of a single enzyme and dynamic disorder Microbial Cell Factory Constraint-based modeling for synthetic biology and metabolic Read more<\/p>\n","protected":false},"author":1,"featured_media":826,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-12","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/pbbp.unist.ac.kr\/index.php?rest_route=\/wp\/v2\/pages\/12","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pbbp.unist.ac.kr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pbbp.unist.ac.kr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pbbp.unist.ac.kr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pbbp.unist.ac.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12"}],"version-history":[{"count":117,"href":"https:\/\/pbbp.unist.ac.kr\/index.php?rest_route=\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":1219,"href":"https:\/\/pbbp.unist.ac.kr\/index.php?rest_route=\/wp\/v2\/pages\/12\/revisions\/1219"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pbbp.unist.ac.kr\/index.php?rest_route=\/wp\/v2\/media\/826"}],"wp:attachment":[{"href":"https:\/\/pbbp.unist.ac.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}